Susana Ferrao Santos on Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.
COMMENT This paper reports that a specific NMDA receptor activation in neurons leads to an increase of α-secretase-mediated APP processing. Interestingly, this effect is inhibited by chelating extracellular calcium with EGTA. Our group has previously shown that a